What question did this study set out to answer?

To identify and validate blood-borne protein biomarkers that can rapidly and accurately detect acute ischemic stroke in an emergency setting.

October 1, 2003Clinical Chemistry

Early Biomarkers of Stroke

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Authors

MRMark A. ReynoldsUniversity of Maryland, Baltimore HKHOWARD J. KIRCHICKAlere (United States)JDJeffrey R. DahlenCitrix (Switzerland)

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Implication

Diagnostic study demonstrates that a five-biomarker blood panel detects acute ischemic stroke within six hours, suggesting a valuable adjunct to emergency neuroimaging.

Key Points

To identify and validate blood-borne protein biomarkers that can rapidly and accurately detect acute ischemic stroke in an emergency setting.
Screened plasma samples from 214 healthy donors and 223 stroke patients (including 82 with acute ischemic stroke) using automated ELISAs for over 50 candidate protein biomarkers.
Conducted univariate analyses followed by multivariate modeling to derive an optimal multi-marker diagnostic algorithm.
Identified five top-performing biomarkers: S-100b, B-type neurotrophic growth factor, von Willebrand factor, matrix metalloproteinase-9, and monocyte chemotactic protein-1.
A panel algorithm requiring three or more elevated markers demonstrated 92% sensitivity and 93% specificity for acute ischemic stroke samples obtained within 6 hours of symptom onset.

Cite This Study

Reynolds et al. (2003) studied this question.

synapsesocial.com/papers/6a775da16789de8d0af72c5a https://doi.org/10.1373/49.10.1733

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Implication

Diagnostic study demonstrates that a five-biomarker blood panel detects acute ischemic stroke within six hours, suggesting a valuable adjunct to emergency neuroimaging.

Early Biomarkers of Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

Early Biomarkers of Stroke

Discussion

Member takes

Implication

Key Points

Cite This Study

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