Key result
Landiolol hydrochloride significantly reduced the occurrence of atrial fibrillation within 72 hours after heart valve surgery compared to control (20.0% vs 53.3%, P=0.015).
Why the study?
Does continuous intravenous landiolol prevent atrial fibrillation in patients in the acute postoperative phase after heart valve surgery?
RCT (n=60)
Open-label
Coin toss method
No
Does continuous intravenous landiolol prevent atrial fibrillation in patients in the acute postoperative phase after heart valve surgery?
Continuous intravenous landiolol significantly reduced the occurrence of postoperative atrial fibrillation in the acute phase after heart valve surgery without aggravating hemodynamics.
Answers are grounded in this paper and cite their sources.
Supports landiolol prophylaxis after valve surgery to curb early AF; extends RCT evidence for perioperative beta-blockade.
The goal of this prospective study was to examine the effects of landiolol hydrochloride on prevention of atrial fibrillation and on hemodynamics in the acute postoperative phase after heart valve surgery. The subjects were 60 patients who underwent valve surgery at our hospital from April 2008 to July 2010. The patients were randomly divided into two groups: the landiolol group (30 patients) and the control (no landiolol) group (30 patients). In the landiolol group, continuous intravenous landiolol was initiated immediately on admission to the intensive care unit at a dose of 10 µg/kg/ minute. Occurrence of atrial fibrillation was compared between the groups over an observation period of 72 hours after surgery. Atrial fibrillation occurred in 6 patients (20%) in the landiolol group and 16 (53.3%) in the control group during the observation period. Landiolol hydrochloride significantly reduced the occurrence of atrial fibrillation in the acute postoperative phase after heart valve surgery. Heart rate was significantly decreased by landiolol, but aggravation of hemodynamics was not observed. These results suggest that landiolol is a useful drug for prevention of atrial fibrillation after valve surgery.
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Sakaguchi et al. (2012) conducted an RCT in Heart valve surgery (n=60). Landiolol hydrochloride vs. No landiolol (control) was evaluated on Occurrence of atrial fibrillation within 72 hours after surgery (p=0.015). Landiolol hydrochloride significantly reduced the occurrence of atrial fibrillation within 72 hours after heart valve surgery compared to control (20.0% vs 53.3%, P=0.015).
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