Key result
The contribution of ASIC1a to evoking the metabolic component of the exercise pressor reflex decreased in a rat model of peripheral artery disease.
Why the study?
The role of ASIC1a in evoking the metabolic component of the exercise pressor reflex in peripheral artery disease is unknown.
ASIC1a's contribution to the metabolic component of the exercise pressor reflex is decreased in a rat model of peripheral artery disease, which may inform future therapeutic targets.
ASIC1a may have limited therapeutic relevance in PAD exercise pressor reflex; hypothesis-generating for human studies.
The role of ASIC1a in evoking the metabolic component of the exercise pressor reflex in peripheral artery disease is unknown. Using a within-rat experimental design, we found that the contribution of ASIC1a decreased in a rat model of peripheral artery disease. These results have key implications to help finding better treatments and improve morbidity, quality of life, and mortality in patients with peripheral artery disease.
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Ducrocq et al. (2020) studied Peripheral artery disease (rat model). ASIC1a was evaluated on Contribution of ASIC1a to the metabolic component of the exercise pressor reflex. The contribution of ASIC1a to evoking the metabolic component of the exercise pressor reflex decreased in a rat model of peripheral artery disease.
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