Key result
Long-term home exercise rehabilitation (6-12 months) significantly improved cardiopulmonary function, including a greater increase in anaerobic threshold oxygen uptake (mean difference 198.89, p=0.0160) compared to short-term rehabilitation in patients with ACS after PCI.
Why the study?
The study aimed to compare the effects of different durations of home exercise rehabilitation on left ventricular remodeling and cardiopulmonary function in patients with ACS treated with PCI.
Does long-term home exercise rehabilitation improve cardiopulmonary function and left ventricular remodeling compared to short-term rehabilitation in patients with ACS after PCI?
Cohort (n=40)
No
Does long-term home exercise rehabilitation improve cardiopulmonary function and left ventricular remodeling compared to short-term rehabilitation in patients with ACS after PCI?
Mean Difference: 198.8876
Absolute Event Rate: 261.4173% vs 62.52966%
p-value: p=0.0160
Long-term home exercise rehabilitation (6-12 months) significantly improves cardiopulmonary function and exercise capacity compared to short-term rehabilitation in patients with ACS after PCI.
Home exercise duration effects on post-PCI remodeling remain uncertain; this cohort study leaves optimal protocols open for randomized trials.
Objectives This study aimed to compare the effects of different durations of home exercise rehabilitation on left ventricular remodeling and cardiopulmonary function in patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI). Methods All patients received individualized home exercise rehabilitation guidance and treatment after discharge from the hospital. Echocardiography and CPET were performed before and after the rehabilitation intervention. The echocardiographic parameters and CPET results of the two groups were compared before and after rehabilitation. Differences between the groups were compared for each parameter. Results Forty patients were enrolled. Patients were divided into long-term home rehabilitation group (6–12 months, n = 18) and short-term home rehabilitation group (3 to < 6 months, n = 22).The CPET parameters ATVO 2 , peak VO 2 /kg, and peak METs in the long-term home rehabilitation group increased after rehabilitation compared with those before rehabilitation ( P < 0.05). Except for the decrease in the VE/VCO 2 slope, which was not statistically significant ( P > 0.05), ATVO 2 , peak VO 2 /HR, peak VO 2 /kg, peak METs, and peak power all increased in the long-term home rehabilitation group compared with the short-term home rehabilitation group( P < 0.05). LVEDd and LVESd were lower in the long-term home rehabilitation group than in the short-term home rehabilitation group( P < 0.05). Multiple regression analysis of the correlation between LVEF and CPET parameters suggested that LVEF had a positive and statistically significant correlation with ATVO 2 and peak power (r = 0.7156828, P = 0.009 and r = 0.457907, P = 0.034). Conclusion Long-term home rehabilitation of patients with ACS after PCI improved the cardiopulmonary function and exercise capacity.
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Zhang et al. (2022) conducted a cohort in Acute coronary syndrome (ACS) post-PCI (n=40). Long-term home exercise rehabilitation vs. Short-term home exercise rehabilitation (3 to <6 months) was evaluated on Change in anaerobic threshold (AT VO2) (MD 198.8876, p=0.0160). Long-term home exercise rehabilitation (6-12 months) significantly improved cardiopulmonary function, including a greater increase in anaerobic threshold oxygen uptake (mean difference 198.89, p=0.0160) compared to short-term rehabilitation in patients with ACS after PCI.
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