What question did this study set out to answer?

To assess the potential cardioprotective effects and underlying molecular mechanisms of sodium thiosulfate in mice with chronic heart failure.

January 1, 2008Pharmacology

Cardioprotective Role of Sodium Thiosulfate on Chronic Heart Failure by Modulating Endogenous H2S Generation

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Authors

USUtpal SenUniversity of Louisville TVThomas Paul VacekLewisGale Hospital Montgomery WHWilliam M. HughesTulane University

Discussion

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Implication

Animal experiment demonstrates sodium thiosulfate prevents ventricular dysfunction in heart failure mice, indicating therapeutic benefits via hydrogen sulfide restoration.

Key Points

To assess the potential cardioprotective effects and underlying molecular mechanisms of sodium thiosulfate in mice with chronic heart failure.
Chronic heart failure was induced in mice using an arteriovenous fistula (AVF) model.
Mice were divided into 4 groups: sham, AVF, sham + STS, and AVF + STS.
Sodium thiosulfate (3 mg/ml) was provided via drinking water for 6 weeks post-surgery.
M-mode echocardiograms revealed ventricular contractile dysfunction and reduced aortic blood flow in AVF mice, which was prevented by STS supplementation.
STS reversed the marked increases in ventricular collagen, MMP-2, MMP-9, and TIMP-1 observed in AVF mice.
AVF attenuated cystathionine-gamma-lyase (CSE) expression and endogenous H2S production without altering CBS; STS normalized ventricular H2S generation and increased tissue responsiveness to H2S.

Cite This Study

Sen et al. (2008) studied this question.

synapsesocial.com/papers/6a775f57d3a6aa87c6bdb8a2 https://doi.org/10.1159/000156486

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January 1, 2008Pharmacology

Cardioprotective Role of Sodium Thiosulfate on Chronic Heart Failure by Modulating Endogenous H2S Generation

View Full Paper

Ask AI

Bookmark

Authors

USUtpal SenUniversity of Louisville TVThomas Paul VacekLewisGale Hospital Montgomery WHWilliam M. HughesTulane University

Discussion

Member takes

Implication

Animal experiment demonstrates sodium thiosulfate prevents ventricular dysfunction in heart failure mice, indicating therapeutic benefits via hydrogen sulfide restoration.

Key Points

To assess the potential cardioprotective effects and underlying molecular mechanisms of sodium thiosulfate in mice with chronic heart failure.
Chronic heart failure was induced in mice using an arteriovenous fistula (AVF) model.
Mice were divided into 4 groups: sham, AVF, sham + STS, and AVF + STS.
Sodium thiosulfate (3 mg/ml) was provided via drinking water for 6 weeks post-surgery.
M-mode echocardiograms revealed ventricular contractile dysfunction and reduced aortic blood flow in AVF mice, which was prevented by STS supplementation.
STS reversed the marked increases in ventricular collagen, MMP-2, MMP-9, and TIMP-1 observed in AVF mice.
AVF attenuated cystathionine-gamma-lyase (CSE) expression and endogenous H2S production without altering CBS; STS normalized ventricular H2S generation and increased tissue responsiveness to H2S.

Cite This Study

Sen et al. (2008) studied this question.

synapsesocial.com/papers/6a775f57d3a6aa87c6bdb8a2 https://doi.org/10.1159/000156486

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