Key result
Genetic and environmental factors, including alcohol intake, obesity, and specific genetic polymorphisms, play important roles in determining susceptibility to advanced ALD and NAFLD.
Population
Individuals with heavy drinking, obesity, insulin resistance, and metabolic syndrome at risk for alcoholic…
Design
Review
Authors
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May inform individualized risk assessment in ALD/NAFLD; leaves open prospective validation before clinical use.
This review highlights the interplay of genetic polymorphisms and environmental factors like diet and obesity in the progression from simple steatosis to advanced liver disease in ALD and NAFLD.
Chris Day (2006) conducted a review in Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). Genetic and environmental risk factors was evaluated. Genetic and environmental factors, including alcohol intake, obesity, and specific genetic polymorphisms, play important roles in determining susceptibility to advanced ALD and NAFLD.
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