Key result
In 90 statistically significant randomized controlled trials in plastic surgery, the median fragility index was 1, indicating that significance often hinges on a single patient's event status.
Why the study?
The fragility index measures how many events a trial result relies on to maintain statistical significance, but the robustness of statistically significant results in plastic surgery randomized controlled trials had not been examined.
Population
90 randomized controlled trials in plastic surgery journals published between 2000 and 2017
Design
Systematic literature search and fragility index analysis
Authors
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Many plastic surgery RCT results may be fragile; hypothesis-generating and should not yet change practice.
Systematic Review (n=90)
Statistically significant results in plastic surgery RCTs demonstrate substantial fragility, often hinging on a single patient's event status.
Chin et al. (2019) conducted a systematic review in Plastic surgery (n=90). Fragility index calculation was evaluated on Fragility index. In 90 statistically significant randomized controlled trials in plastic surgery, the median fragility index was 1, indicating that significance often hinges on a single patient's event status.
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