What question did this study set out to answer?

To establish an immunocompetent mouse model of HPV-positive head and neck squamous cell carcinoma and characterize its adaptive immune microenvironment relative to human disease.

January 3, 2025Cancer Immunology ImmunotherapyOpen Access

Characterization of the adaptive immune response in a mouse model for HPV-positive head and neck squamous cell carcinoma with implications to human disease

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Authors

FOFranziska OliveriUniversity Hospital Ulm LNLinda Neher RPRonja PscheidUniversity of Nottingham

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Implication

Preclinical study reveals shared immunosuppressive T-cell and B-cell profiles in mouse and human HPV-positive head and neck cancer, highlighting potential targets beyond PD-1 blockade.

Key Points

To establish an immunocompetent mouse model of HPV-positive head and neck squamous cell carcinoma and characterize its adaptive immune microenvironment relative to human disease.
Engineered a mouse cell line expressing HPV16 E6/E7 oncogenes and constitutively active H-Ras, subsequently implanted orthotopically into the floor of the mouth in immunocompetent mice.
Profiled tumor-infiltrating T-cell and B-cell phenotypes and immunoregulatory pathways in tumor-bearing mice and comparative tumor samples from HPV-positive cancer patients.
Tumor-infiltrating T cells in both mice and human patient samples displayed elevated expression of adenosine-producing ectoenzymes CD39 and CD73, along with checkpoint markers PD-1, LAG-3, and GITR.
Tumor-bearing mice exhibited increased systemic and local B-cell responses, characterized by expanded germinal center, immunoregulatory marginal zone, and follicular B-cell subsets.

Cite This Study

Oliveri et al. (2025) studied this question.

synapsesocial.com/papers/6a7769ecc5ab23c76cec9e5e https://doi.org/10.1007/s00262-024-03907-y

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Implication

Preclinical study reveals shared immunosuppressive T-cell and B-cell profiles in mouse and human HPV-positive head and neck cancer, highlighting potential targets beyond PD-1 blockade.

Characterization of the adaptive immune response in a mouse model for HPV-positive head and neck squamous cell carcinoma with implications to human disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Characterization of the adaptive immune response in a mouse model for HPV-positive head and neck squamous cell carcinoma with implications to human disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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