Key result
Repeated carotid artery catheterization for serial IVUS evaluation is feasible and safe, revealing that peak neointimal proliferation varies considerably from 6 to 12 weeks among individual animals.
A swine model using repeated carotid artery catheterization is feasible and safe for evaluating the serial time course of in-stent neointimal proliferation, demonstrating significant inter-animal variability in the timing of peak proliferation.
Does not support clinical translation of serial carotid IVUS; leaves open optimal assessment windows due to inter-animal variability in neointimal proliferation.
The aim of this study was to propose a new animal model evaluating the serial time course of in-stent stenosis by repeated carotid artery catheterization in the same animal. 16 bare-metal stents were implanted in the normal external and internal iliac artery of 8 miniature pigs. Repeated measurements were performed in the same animal every 2 weeks for 12 weeks through carotid artery catheterization. The time course and peak neointimal proliferation were evaluated by intravascular ultrasound. Health of all animals was assessed by clinical and hematological examinations. As a result, 7 times of carotid artery catheterization was performed per pig, but all animals remained healthy without both any complications and hematological inflammatory abnormalities. The time course of neointimal proliferation of each stent was observed from the stage of hyperplasia to partial regression. The peak neointimal proliferation varied from 6 to 12 weeks despite implantation of identical stents using the same deployment method. In conclusion, repeated carotid artery catheterization to the same animal is feasible without animal health deterioration. This model should be useful to evaluate the time course of neointimal proliferation after stent deployment in preclinical study.
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Ishikawa et al. (2018) studied In-stent stenosis (animal model) (n=8). Bare-metal stent implantation with repeated carotid artery catheterization was evaluated on Peak percent in-stent volume obstruction (%VO). Repeated carotid artery catheterization for serial IVUS evaluation is feasible and safe, revealing that peak neointimal proliferation varies considerably from 6 to 12 weeks among individual animals.
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