Key result
Tacrolimus-eluting stents demonstrated significantly lower endothelialization rates at 7 days (79%) compared to stainless steel (95%) and cobalt-chromium stents (98%) in a swine model (P=0.01).
Why the study?
Does a tacrolimus-eluting stent compared to bare metal stents affect the rate of endothelialization in a normal coronary swine model?
Does a tacrolimus-eluting stent compared to bare metal stents affect the rate of endothelialization in a normal coronary swine model?
Absolute Event Rate: 79% vs 95%
p-value: p=.01
In a normal swine coronary model, tacrolimus-eluting stents showed delayed endothelialization compared to bare metal stents at 3 and 7 days.
Authors
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Warrants caution with tacrolimus-eluting stents; leaves open effects on human endothelialization pending clinical studies.
Prado et al. (2011) studied Nonatherosclerotic swine coronary arteries (n=11). Tacrolimus-eluting stent (TES) vs. Stainless steel (SS) and cobalt-chromium stents (CCS) was evaluated on Endothelialization rate at 7 days (p=.01). Tacrolimus-eluting stents demonstrated significantly lower endothelialization rates at 7 days (79%) compared to stainless steel (95%) and cobalt-chromium stents (98%) in a swine model (P=0.01).
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