May 1, 1994Coronary Artery Disease
Comparison of three porcine restenosis models
Why the study?
Does hypercholesterolemia and endothelial abrasion increase neointimal thickening compared to stenting alone in porcine restenosis models?
Population
23 Hanford miniature swine
Comparison
Model A: cholesterol-raising diet, endothelial… vs Model C: normal swine food and stenting
Design
Preclinical
Follow-up
4 weeks post-stenting
Authors
Discussion
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Member takes
Implication
Stenting alone drives neointimal thickening in swine models; leaves open hypercholesterolemia's role in clinical restenosis.
Structured PICO
Does hypercholesterolemia and endothelial abrasion increase neointimal thickening compared to stenting alone in porcine restenosis models?
P
Population
23 Hanford miniature swine
I
Intervention
Model A (n=9): cholesterol-raising diet, endothelial abrasion of LAD and CFX, and balloon-expandable tantalum coil stents in RCA, LAD, and CFX; Model B (n=7): cholesterol-raising diet and stenting
C
Comparator
Model C (n=7): normal swine food and stenting (no endothelial abrasion or hypercholesterolemia)
O
Outcome
Change in minimal lumen diameter by quantitative angiography and percentage area stenosis by morphometric analysis 4 weeks post-stentingsurrogate
Intracoronary stenting alone is the major stimulus for neointimal thickening in swine models, with hypercholesterolemia and endothelial abrasion adding no significant effect.
Cite This Study
Grinstead et al. (1994) studied this question.