Why the study?
Does paclitaxel-eluting stent implantation compared to bare metal stents alter vascular responses in a diabetic/hypercholesterolemic porcine model?
Does paclitaxel-eluting stent implantation compared to bare metal stents alter vascular responses in a diabetic/hypercholesterolemic porcine model?
A diabetic/hypercholesterolemic swine model augments differences in vascular responses between paclitaxel-eluting and bare metal stents, demonstrating increased neointimal area, delayed reendothelialization, and greater inflammation compared to standard nonatherosclerotic models.
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These animal data should not guide stent choice; leaves open metabolic effects on healing in human diabetics.
Llano et al. (2011) studied this question.
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