Why the study?
Does implantation of sirolimus-eluting or paclitaxel-eluting stents cause different inflammatory responses compared to bare metal stents in porcine coronary arteries?
Population
58 domestic swine with noninjured coronary arteries
Comparison
Sirolimus-eluting stents and paclitaxel-eluting… vs Bare metal stents (Bx SONIC and Liberté)
Design
Preclinical
Follow-up
up to 180 days
Authors
Loading...
Highlights species-specific stent inflammation in swine; leaves open human relevance and clinical translation.
Does implantation of sirolimus-eluting or paclitaxel-eluting stents cause different inflammatory responses compared to bare metal stents in porcine coronary arteries?
In a porcine model, sirolimus-eluting stents caused significantly more diffuse granulomatous inflammation than paclitaxel-eluting or bare metal stents at 90 and 180 days.
Wilson et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: