Key result
Overlapping paclitaxel-eluting stents in a porcine model reduced late lumen loss (0.46 vs 1.30 mm, P=0.01) but caused marked intramural thrombi compared to bare-metal stents.
Why the study?
Does overlapping paclitaxel-eluting stent implantation compared to bare-metal stents affect angioscopic and histopathologic outcomes in pig coronary arteries at 1 month?
Population
Pig coronary arteries (n=9 pigs)
Comparison
Overlapping paclitaxel-eluting stents (PES) vs Overlapping bare-metal stents (BMS)
Design
Preclinical
Follow-up
1 month
Authors
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May increase intramural thrombosis risk with overlapping paclitaxel-eluting stents; leaves open human applicability and need for clinical trials.
Does overlapping paclitaxel-eluting stent implantation compared to bare-metal stents affect angioscopic and histopathologic outcomes in pig coronary arteries at 1 month?
Absolute Event Rate: 0.46% vs 1.3%
p-value: p=0.01
In a porcine model, overlapping paclitaxel-eluting stents reduce neointimal thickness but are associated with marked intramural thrombi and impaired adjacent endothelial function compared to bare-metal stents at 1 month.
Shinke et al. (2008) studied Coronary stenting (porcine model) (n=9). Overlapping paclitaxel-eluting stents (PES) vs. Bare-metal stents (BMS) was evaluated on Late lumen loss (p=0.01). Overlapping paclitaxel-eluting stents in a porcine model reduced late lumen loss (0.46 vs 1.30 mm, P=0.01) but caused marked intramural thrombi compared to bare-metal stents.
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