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The study investigates the metabolism and distribution of vitamin D3-3H in human subjects and its excretion pathways.

Metabolism of Vitamin D3-3H in Human Subjects: Distribution in Blood, Bile, Feces, and Urine*

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Randomized trial explores vitamin D metabolism and excretion in humans, suggesting key implications for health.

The study investigates the metabolism and distribution of vitamin D3-3H in human subjects and its excretion pathways.
Administered vitamin D3-3H intravenously to 14 subjects: 7 normal, 3 with biliary fistulas, and 4 with cirrhosis.
Measured plasma half-times, urinary radioactivity, and analyzed metabolites in bile and feces over a 48-hour period.
Isolated biologically active metabolites from plasma to evaluate metabolic transformation.
Plasma D3-3H half-times were found to range from 20 to 30 hours.
Urine accounted for an average of 2.4% of the administered dose, containing mainly altered vitamin D metabolites, with 26% in conjugated form.
Cirrhosis patients exhibited a slower plasma disappearance of vitamin D3-3H and reduced urinary glucuronide metabolite excretion.

Avioli et al. (1967) studied this question.

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