Key result
A polymeric TAVR valve prototype demonstrated a 42% larger opening area and 27% higher flow rate compared to a polymeric SAVR valve, with similar wall shear and mechanical stresses in FSI models.
Population
Fluid-structure interaction (FSI) models and Vivitro pulse duplicator experiments of polymeric aortic valves
Comparison
Polymeric TAVR valve prototype vs Polymeric SAVR valve
Design
Preclinical
Authors
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Crimping may damage current TAVR valves, risking calcification and thrombosis; leaves open whether purpose-designed valves improve durability.
A novel polymeric TAVR valve prototype demonstrated enhanced hemodynamic performance with comparable mechanical stresses to a polymeric SAVR valve in computational models.
Ghosh et al. (2018) studied Calcified aortic valve disease. Polymeric TAVR valve prototype vs. Polymeric SAVR valve was evaluated on Hemodynamic performance and mechanical stresses (opening area, flow rate, wall shear stress, mechanical stress). A polymeric TAVR valve prototype demonstrated a 42% larger opening area and 27% higher flow rate compared to a polymeric SAVR valve, with similar wall shear and mechanical stresses in FSI models.
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