Key result
Ligatin and MCT-1/DENR promote efficient eIF2-independent recruitment of initiator tRNA to 40S/mRNA complexes and release of deacylated tRNA and mRNA from recycled 40S subunits.
Population
In vitro/molecular models of eukaryotic translation initiation (Sindbis virus 26S mRNA, HCV-like IRESs)
Design
Preclinical
Authors
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Hypothesis-generating for viral evasion of stress-induced translation shutdown; leaves open human validation and therapeutic targeting.
Ligatin and MCT-1/DENR facilitate eIF2-independent translation initiation and ribosomal recycling, explaining how certain viral mRNAs resist translation inhibition during cellular stress.
Skabkin et al. (2010) studied this question. Ligatin and MCT-1/DENR was evaluated on eIF2-independent recruitment of Met-tRNA(Met)(i) to 40S/mRNA complexes. Ligatin and MCT-1/DENR promote efficient eIF2-independent recruitment of initiator tRNA to 40S/mRNA complexes and release of deacylated tRNA and mRNA from recycled 40S subunits.
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