Key result
The SPV9 IRES binds directly to 40S subunits and eIF3 like HP IRESs, but uniquely promotes eIF2-independent binding of initiator tRNA to the 40S subunit.
Population
In vitro reconstitution system for Simian picornavirus type 9 5'-untranslated region internal ribosomal…
Comparison
Translation initiation factors vs Hepacivirus/pestivirus (HP) IRESs
Design
Preclinical
Authors
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SPV9 IRES mechanism extends HP IRES models; leaves open relevance to mammalian or cardiac translation systems.
The SPV9 IRES shares functional similarities with HP IRESs but exhibits unique translation initiation factor requirements, including eIF2-independent initiator tRNA binding.
Breyne et al. (2007) studied Simian picornavirus type 9 (SPV9) translation initiation. SPV9 IRES vs. Hepacivirus/pestivirus (HP) IRESs was evaluated on Ribosomal binding and translation initiation factor requirements. The SPV9 IRES binds directly to 40S subunits and eIF3 like HP IRESs, but uniquely promotes eIF2-independent binding of initiator tRNA to the 40S subunit.
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