Population
Picornavirus mRNA translation models
Comparison
Substitution of TMEV IRES with FMDV IRES… vs Wild-type TMEV IRES
Design
Preclinical
Authors
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May enable tissue-specific picornavirus attenuation via ITAF engineering; leaves open human disease relevance.
PTB and ITAF(45) act as RNA chaperones controlling IRES functional states, providing a basis for cell-specific translational control of certain mRNAs.
Pilipenko et al. (2000) studied this question.
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