Population
Type 2 internal ribosomal entry sites of encephalomyocarditis virus and foot-and-mouth disease virus
Design
Preclinical
Authors
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Hypothesis-generating for IRES-ITAF mechanisms; leaves open validation in disease models and therapeutic translation.
ITAFs induce similar compact conformational changes in type 2 picornavirus IRESs to support efficient ribosomal recruitment.
Yu et al. (2011) studied this question.
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