Population
Encephalomyocarditis virus internal ribosomal entry site (IRES) and eukaryotic initiation factors
Design
Preclinical
Authors
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No immediate clinical implications for EMCV myocarditis; leaves open whether eIF4G-eIF4A targeting is viable in vivo.
The study elucidates the molecular mechanism by which eIF4G and eIF4A prepare the encephalomyocarditis virus IRES for ribosome binding through specific conformational changes.
Kolupaeva et al. (2002) studied this question.
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