Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites

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Population

Viral internal ribosomal entry sites, specifically type 1 and type 2

Design

Preclinical

Authors

Discussion

Extends mechanistic insight into type 1 IRES translation; hypothesis-generating and should not yet change clinical practice.

Population

Viral internal ribosomal entry sites (IRESs), specifically type 1 (e.g., poliovirus) and type 2 (e.g., encephalomyocarditis virus)

Intervention

Interaction with eukaryotic initiation factor (eIF) 4G and eIF4A

Outcome

Binding of eIF4G to domain V of type 1 IRESs and subsequent conformational changes and translational activity

The mechanism of translation initiation on type 1 IRESs involves direct functional interaction with eIF4G, similar to type 2 IRESs.

Breyne et al. (2009) studied this question.

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