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December 1, 1996Molecular and Cellular BiologyOpen Access

Functional Dissection of Eukaryotic Initiation Factor 4F: the 4A Subunit and the Central Domain of the 4G Subunit Are Sufficient To Mediate Internal Entry of 43S Preinitiation Complexes

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Population

in vitro reconstituted translation system from purified translation components

Design

Preclinical

Authors

TPTatyana V. PestovaISIvan N. ShatskyCHChristopher U.T. Hellen

Discussion

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Overview

May guide IRES targeting in preclinical models; leaves open translation to human cardiovascular mechanisms.

Structured PICO

P
Population
in vitro reconstituted translation system from purified translation components
I
Intervention
eIF4A and the central third of eIF4G
O
Outcome
IRES-mediated translation initiation and binding to the encephalomyocarditis virus IRESsurrogate

The central domain of eIF4G and eIF4A are sufficient to mediate internal ribosomal entry site (IRES) translation initiation.

Cite This Study

Pestova et al. (1996) studied this question.

synapsesocial.com/papers/6a7c113ba540d02696c2bf9fhttps://doi.org/10.1128/mcb.16.12.6870
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Canonical Eukaryotic Initiation Factors Determine Initiation of Translation by Internal Ribosomal Entry1996 · 499 citations
  2. 2Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo1989 · 419 citations
  3. 3Conservation of the secondary structure elements of the 5' untranslated region of cardio- and aphthovirus RNAs1989 · 203 citations
  4. 4Mechanism and regulation of eukaryotic protein synthesis1992 · 600 citations
  5. 5The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.1993 · 280 citations