July 1, 1998Journal of Biological ChemistryOpen Access

Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA

View Full Paper

Ask AI

Bookmark

Population

Encephalomyocarditis virus (EMCV) RNA and eukaryotic initiation factor 4G (eIF4G) complexes

Design

Preclinical

Authors

VKVictoria KolupaevaColumbia University Irving Medical Center TPTatyana V. PestovaBoston University CHChristopher U.T. HellenBoston University

Discussion

Member takes

Implication

Advances EMCV IRES structural biology; leaves open conservation, druggability, and relevance to other IRES-driven translations.

Structured PICO

Population

Encephalomyocarditis virus (EMCV) RNA and eukaryotic initiation factor 4G (eIF4G) complexes

Intervention

Chemical and enzymatic probing

Outcome

Mapping the eIF4G binding site on the EMCV IRES

The study identifies the specific structural element within the EMCV IRES required for eIF4G binding, advancing understanding of cap-independent translation initiation.

Cite This Study

Kolupaeva et al. (1998) studied this question.

synapsesocial.com/papers/6a6fe6d9660549caf2c470fa https://doi.org/10.1074/jbc.273.29.18599

View Full Paper

Ask AI

Bookmark

Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Translation Eukaryotic Initiation Factor 4G Recognizes a Specific Structural Element within the Internal Ribosome Entry Site of Encephalomyocarditis Virus RNA

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider