November 10, 2003Journal of VirologyOpen Access

Conserved Nucleotides within the J Domain of the Encephalomyocarditis Virus Internal Ribosome Entry Site Are Required for Activity and for Interaction with eIF4G

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Population

Encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES) elements

Comparison

Mutagenesis of four highly conserved nucleotides… vs Wild-type IRES element

Design

Preclinical

Authors

Discussion

Supports IRES-targeted antiviral strategies in models; leaves open translation to human viral therapies.

Population

Encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES) elements

Intervention

Mutagenesis of four highly conserved nucleotides (A704, C705, G723, and A724) within the J domain

Comparator

Wild-type IRES element

Outcome

Efficiency of directing internal initiation of translation and ability to interact with translation initiation factor eIF4G

Conserved nucleotides in the J domain of the EMCV IRES are essential for efficient translation initiation and interaction with eIF4G.

Clark et al. (2003) studied this question.

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