Population
In vitro model using ascites carcinoma Krebs-2 cell extracts and encephalomyocarditis virus RNA derivatives
Comparison
Various deletions and mutations in the internal… vs Intact/wild-type IRES constructs
Design
Preclinical
Authors
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No immediate clinical implications; leaves open whether IRES reconstitution applies beyond EMCV models.
The study identifies specific binding sites for p58/p60 proteins on the EMCV IRES and demonstrates that IRES initiation activity can be reconstituted from unlinked RNA fragments, supporting a non-scanning mechanism for internal ribosome entry.
Borovjagin et al. (1991) studied this question.
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