Population
Encephalomyocarditis virus (EMCV) RNA internal ribosomal entry site (IRES) and HeLa cells
Comparison
Mutations within the J-K sequences of EMCV vs Wild-type EMCV IRES
Design
Preclinical
Authors
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Identifies J-K stem-loop as potential antiviral target in EMCV; leaves open translation to human therapies.
Mutations in the J-K stem-loop region of the EMCV IRES severely impair translation and viral infectivity, highlighting its critical role in cap-independent translation.
Hoffman et al. (1995) studied this question.
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