September 1, 1996Journal of VirologyOpen Access

Revertant analysis of J-K mutations in the encephalomyocarditis virus internal ribosomal entry site detects an altered leader protein

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Population

Encephalomyocarditis virus internal ribosomal entry site (IRES) mutants

Design

Preclinical

Authors

MHMichael A. HoffmanUnited Christian Hospital APA C PalmenbergUniversity of Wisconsin–Madison

Discussion

Member takes

Implication

Refines EMCV IRES structural model; leaves open leader protein mutation effects on in vivo fitness.

Structured PICO

Population

Encephalomyocarditis virus internal ribosomal entry site (IRES) mutants

Intervention

Substitution and deletion mutations into the J-K elements, isolation of 60 larger-plaque revertant viruses

Outcome

Viral plaque size and cell-free translational activitysurrogate

Structural analysis of encephalomyocarditis virus IRES revertants refines the structural model of the IRES and identifies a leader protein mutation that affects viral plaque size.

Cite This Study

Hoffman et al. (1996) studied this question.

synapsesocial.com/papers/6a7cfe0a3d640844b95e05b7 https://doi.org/10.1128/jvi.70.9.6425-6430.1996

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Revertant analysis of J-K mutations in the encephalomyocarditis virus internal ribosomal entry site detects an altered leader protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Revertant analysis of J-K mutations in the encephalomyocarditis virus internal ribosomal entry site detects an altered leader protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider