Population
In vitro model studying mammalian eukaryotic initiation factor 4GI and encephalomyocarditis virus internal…
Comparison
Mutational analysis of eIF4GI and association… vs eIF4GI alone (without eIF4A) or wild-type eIF4GI
Design
Preclinical
Authors
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May guide IRES-targeted antivirals; extends translation initiation models but leaves open in vivo validation.
The eIF4G-eIF4A complex, rather than eIF4G alone, is required for specific high-affinity binding to the EMCV IRES and for internal initiation of translation.
Lomakin et al. (2000) studied this question.
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