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September 1, 1999Journal of Virology

Translation Initiation Factor eIF4B Interacts with a Picornavirus Internal Ribosome Entry Site in both 48S and 80S Initiation Complexes Independently of Initiator AUG Location

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Authors

KOKerstin OchsJustus-Liebig-Universität Gießen RRRenéC. Rust MNMichael NiepmannJustus-Liebig-Universität Gießen

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Implication

eIF4B remains bound to FMDV IRES in 80S ribosomes unlike cellular mRNAs; leaves open antiviral targeting in picornaviruses.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Ochs et al. (1999) studied this question.

synapsesocial.com/papers/6a87e81d350e059174ad3f7e https://doi.org/10.1128/jvi.73.9.7505-7514.1999

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Interaction of Eukaryotic Initiation Factor eIF4B with the Internal Ribosome Entry Site of Foot-and-Mouth Disease Virus Is Independent of the Polypyrimidine Tract-Binding Protein1999 · 30 citations
2Canonical Eukaryotic Initiation Factors Determine Initiation of Translation by Internal Ribosomal Entry1996 · 502 citations
3A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initation of hepatitis C and classical swine fever virus RNAs1998 · 739 citations
4RNA-protein interactions in regulation of picornavirus RNA translation1996 · 251 citations
5A cellular 57 kDa protein binds to two regions of the internal translation initiation site of foot‐and‐mouth disease virus1990 · 67 citations