Population
Foot-and-mouth disease virus internal ribosome entry site and eukaryotic translation initiation factor eIF4G
Comparison
Mutagenesis of stem-loop 4 subdomains vs Wild-type FMDV IRES
Design
Preclinical
Authors
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Hypothesis-generating for eIF4G-targeted antivirals in FMDV; leaves open translation to mammalian or clinical settings.
The interaction of eIF4G with the stem-loop 4 of the FMDV IRES is crucial for the initiation of viral translation.
Saleh et al. (2001) studied this question.
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