Population
Foot-and-mouth disease virus (FMDV) internal ribosome entry site (IRES) and eIF4G binding models
Comparison
Mutations in the conserved element of the… vs Wild-type/unmutated conserved element
Design
Preclinical
Authors
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May guide IRES-targeted antivirals; leaves open effects on FMDV fitness in animal models.
Mutations in the conserved element of the FMDV IRES impair eIF4G binding and translation, which cannot be rescued by increased initiation factor concentrations.
Bassili et al. (2004) studied this question.
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