Interaction of Eukaryotic Initiation Factor eIF4B with the Internal Ribosome Entry Site of Foot-and-Mouth Disease Virus Is Independent of the Polypyrimidine Tract-Binding Protein

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Population

Foot-and-mouth disease virus (FMDV) internal ribosome entry site (IRES) and reticulocyte lysate

Comparison

Mutations in IRES stem-loop 4 and removal of the… vs Wild-type IRES

Design

Preclinical

Authors

Discussion

eIF4B-FMDV IRES interaction is essential and PTB-independent; leaves open validation in infected cells and as antiviral target.

Population

Foot-and-mouth disease virus (FMDV) internal ribosome entry site (IRES) and reticulocyte lysate

Intervention

Mutations in IRES stem-loop 4 and removal of the major PTB-binding site

Comparator

Wild-type IRES

Outcome

Binding of eIF4B and translation efficiencysurrogate

The interaction of eIF4B with the FMDV IRES is essential for IRES function but independent of polypyrimidine tract-binding protein (PTB).

Rust et al. (1999) studied this question.

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