August 1, 2020Seminars in Musculoskeletal RadiologyOpen Access

Quantitative Imaging in Muscle Diseases with Focus on Non-proton MRI and Other Advanced MRI Techniques

Q: What is the clinical evidence from this study?

Study design: Review. Population: Muscle diseases (myopathies, muscular channelopathies, muscular dystrophies). Intervention: Quantitative MRI and non-proton MRI (e.g., 23Na MRI).

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Key result

Quantitative and non-proton MRI techniques, such as 23Na MRI, provide deep insights into muscle pathophysiology and serve as valuable biomarkers for diagnosing and monitoring muscle diseases.

Why the study?

Neuromuscular imaging is gaining clinical relevance in diagnosing and monitoring inherited and acquired muscle diseases, and advanced quantitative MRI techniques provide deeper insights into muscle pathophysiology.

Design

Review article

Authors

MWMarc‐André Weber ANArmin M. Nagel HKHermien E. Kan

Discussion

Member takes

Overview

Whole-body MRI may refine pattern-based diagnosis in muscle diseases; leaves open its validation as a standardized trial endpoint.

Structured PICO

Population

Patients with inherited and acquired muscle diseases (e.g., muscular dystrophies, channelopathies)

Intervention

Quantitative MRI techniques, with a focus on non-proton MRI (e.g., 23Na, 35Cl)

Advanced quantitative MRI techniques, particularly non-proton imaging like 23Na MRI, offer valuable insights into muscle pathophysiology and hold promise as diagnostic and monitoring biomarkers in neuromuscular diseases.

Limitations

The in vivo signal-to-noise ratio of 23Na MRI is four orders of magnitude lower compared with 1H MRI.
Requires high-field MRI systems and ultrashort echo time pulse sequences for quantitative imaging.

Cite This Study

Weber et al. (2020) conducted a review in Muscle diseases (myopathies, muscular channelopathies, muscular dystrophies). Quantitative MRI and non-proton MRI (e.g., 23Na MRI) was evaluated. Quantitative and non-proton MRI techniques, such as 23Na MRI, provide deep insights into muscle pathophysiology and serve as valuable biomarkers for diagnosing and monitoring muscle diseases.

synapsesocial.com/papers/6a77750c7ecc675f86ae6eb2 https://doi.org/10.1055/s-0040-1712955

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August 1, 2020Seminars in Musculoskeletal RadiologyOpen Access

Quantitative Imaging in Muscle Diseases with Focus on Non-proton MRI and Other Advanced MRI Techniques

View Full Paper

Ask AI

Bookmark

Key result

Quantitative and non-proton MRI techniques, such as 23Na MRI, provide deep insights into muscle pathophysiology and serve as valuable biomarkers for diagnosing and monitoring muscle diseases.

Why the study?

Design

Review article

Authors

MWMarc‐André Weber ANArmin M. Nagel HKHermien E. Kan

Discussion

Member takes

Overview

Whole-body MRI may refine pattern-based diagnosis in muscle diseases; leaves open its validation as a standardized trial endpoint.

Structured PICO

Population

Patients with inherited and acquired muscle diseases (e.g., muscular dystrophies, channelopathies)

Intervention

Quantitative MRI techniques, with a focus on non-proton MRI (e.g., 23Na, 35Cl)

Limitations

The in vivo signal-to-noise ratio of 23Na MRI is four orders of magnitude lower compared with 1H MRI.
Requires high-field MRI systems and ultrashort echo time pulse sequences for quantitative imaging.

Cite This Study

synapsesocial.com/papers/6a77750c7ecc675f86ae6eb2 https://doi.org/10.1055/s-0040-1712955

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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