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Does electrophysiological study-guided drug selection prevent recurrent symptoms in patients with rapid AV nodal re-entrant tachycardias?
Does electrophysiological study-guided drug selection prevent recurrent symptoms in patients with rapid AV nodal re-entrant tachycardias?
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Electrophysiological study is a useful means of selecting effective drug therapy in patients with severe, symptomatic AV nodal re-entrant tachycardias.
Five patients with recurrent syncope or pre-syncope due to rapid supraventricular tachycardias underwent electrophysiological study. In each patient, an AV nodal re-entrant tachycardia could be induced. By leaving a coronary sinus catheter in place, the effects of drugs on the ability to induce tachycardia could be tested on sequential days. Drug effects were highly variable, but in each patient it was possible to determine a drug which prevented induction of tachycardia. Patients treated with this drug have had no recurrent symptoms or tachycardias with a followup of 4-21 months. Although AV nodal re-entry is highly dependent on autonomic tone, electrophysiological study appears to be a useful means of selecting therapy in patients with severe, symptomatic tachycardias.
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Wiener et al. (1982) studied this question.
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