What question did this study set out to answer?

To evaluate whether stearic acid-based solid lipid nanoparticles loaded with glucocorticoids can safely enter auditory cells and shield them against cisplatin-induced ototoxicity.

September 14, 2019Journal of Clinical MedicineOpen Access

Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity

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Authors

BCBlanca CervantesUniversidad Anáhuac Puebla LALide AranaUniversity of the Basque Country SMSilvia Murillo‐CuestaInstituto de Salud Carlos III

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Implication

In vitro study demonstrates enhanced protection by hydrocortisone-loaded nanoparticles in auditory cells, suggesting a potential strategy to prevent cisplatin-induced hearing loss.

Key Points

To evaluate whether stearic acid-based solid lipid nanoparticles loaded with glucocorticoids can safely enter auditory cells and shield them against cisplatin-induced ototoxicity.
Synthesized stearic acid-based solid lipid nanoparticles (SLNs) and characterized their particle size, polydispersity index, and zeta potential.
Evaluated intracellular uptake in auditory HEI-OC1 cells using rhodamine-loaded SLNs and assessed nanocarrier safety across varying doses.
Treated HEI-OC1 cells with cisplatin alone or in combination with free versus SLN-encapsulated dexamethasone and hydrocortisone to assess cell survival.
Stearic acid-based SLNs exhibited optimal physicochemical properties, achieved high cellular uptake in HEI-OC1 cells, and showed no intrinsic ototoxicity across a broad dose range.
Encapsulation into SLNs amplified the cytoprotective capacity of low-dose hydrocortisone and extended HEI-OC1 cell survival after cisplatin challenge.

Cite This Study

Cervantes et al. (2019) studied this question.

synapsesocial.com/papers/6a777a43d8eb58afc2bde568 https://doi.org/10.3390/jcm8091464

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Implication

In vitro study demonstrates enhanced protection by hydrocortisone-loaded nanoparticles in auditory cells, suggesting a potential strategy to prevent cisplatin-induced hearing loss.

Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity

Discussion

Member takes

Implication

Key Points

Cite This Study

Solid Lipid Nanoparticles Loaded with Glucocorticoids Protect Auditory Cells from Cisplatin-Induced Ototoxicity

Discussion

Member takes

Implication

Key Points

Cite This Study

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