Key result
Maternal antibodies suppress oral rotavirus vaccine immunogenicity by accelerating viral clearance and blunting antiviral gene programs, preventing germinal center formation in a neonatal mouse model.
Maternal antibodies interfere with oral rotavirus vaccination in neonatal mice by accelerating viral clearance, preventing the formation of germinal centers and subsequent infant immune responses.
Child morbidity and mortality from infectious diseases remain high in many low- and middle-income countries, highlighting the need for the development of more effective vaccination strategies. In this issue of The EMBO Journal, Chandler et al, demonstrate in a neonatal mouse model that maternal antibodies interfere with oral rotavirus vaccination by accelerating viral clearance, offering a mechanistic rationale for reduced vaccine performance in high-burden settings.
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Mollin et al. (2025) conducted an editorial in Rotavirus infection. Maternal antibodies vs. Absence of maternal antibodies was evaluated. Maternal antibodies suppress oral rotavirus vaccine immunogenicity by accelerating viral clearance and blunting antiviral gene programs, preventing germinal center formation in a neonatal mouse model.
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