Key result
Higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion, whereas breastfeeding withholding has no effect on vaccine responses.
Why the study?
Does maternal immunity affect rotavirus vaccine performance in infants in low- and middle-income countries?
Does maternal immunity affect rotavirus vaccine performance in infants in low- and middle-income countries?
Higher levels of transplacental rotavirus-specific IgG, but not breastfeeding, contribute to reduced rotavirus vaccine seroconversion in infants in LMICs.
High maternal rotavirus IgG may blunt infant vaccine responses; leaves open strategies to improve seroconversion.
The role of maternal immunity, received by infants either transplacentally or orally from breast milk, in rotavirus vaccine (RV) performance is evaluated here. Breastfeeding withholding has no effect on vaccine responses, but higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion. The gaps in knowledge on the factors associated with low RV efficacy in low- and middle-income countries (LMIC) remain, and further research is needed to shed more light on these issues.
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Mwila-Kazimbaya et al. (2016) conducted a review in Rotavirus vaccine performance. Maternal immunity (transplacental IgG and breast milk) was evaluated on Vaccine seroconversion and responses. Higher levels of transplacental rotavirus-specific IgG antibody contribute to reduced vaccine seroconversion, whereas breastfeeding withholding has no effect on vaccine responses.
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