Key result
Withholding breastfeeding around the time of oral rotavirus vaccination did not improve infant seroconversion rates compared to breastfeeding (26% vs 27%; p=0.92).
Why the study?
Does withholding breastfeeding improve seroconversion to oral rotavirus vaccine in infants?
Population
400 mother-infant pairs in New Delhi, India, with infants aged 6-7 weeks at enrollment.
Comparison
Withholding breastfeeding during the 30 min… vs Encouraged to breastfeed around the time of…
Design
RCT, randomized into two equal groups
Follow-up
4 weeks after the second vaccine dose
Authors
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No benefit from withholding breastfeeding at rotavirus vaccination; confirms breastfeeding does not impair seroconversion.
RCT (n=400)
1:1
Does withholding breastfeeding improve seroconversion to oral rotavirus vaccine in infants?
Absolute Event Rate: 26% vs 27%
p-value: p=0.92
Withholding breastfeeding around the time of oral rotavirus vaccination does not enhance the immune response in infants.
Rongsen‐Chandola et al. (2014) conducted an RCT in Rotavirus vaccination (n=400). Withholding breastfeeding vs. Encouraged to breastfeed was evaluated on Seroconversion (infant serum anti-VP6 IgA antibody level of ≥20 IU/mL 4 weeks after the second vaccine dose and a ≥4-fold rise from baseline) (p=0.92). Withholding breastfeeding around the time of oral rotavirus vaccination did not improve infant seroconversion rates compared to breastfeeding (26% vs 27%; p=0.92).
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