Why the study?
Does ROTAVAC coadministration reduce the immune response to routine childhood vaccines in 6-week-old infants?
Population
Infants aged 6 weeks in urban neighborhoods of Delhi, India
Comparison
Three doses of Oral Rotavirus Vaccine ROTAVAC®… vs Three doses of placebo coadministered with the…
Design
RCT, randomized, double-blind
Follow-up
4 weeks post dose 3
Authors
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Supports coadministration of ROTAVAC with routine childhood vaccines without immunogenicity concerns; confirms non-interference in Indian infants.
Does ROTAVAC coadministration reduce the immune response to routine childhood vaccines in 6-week-old infants?
ROTAVAC can be safely coadministered with routine childhood vaccines without interfering with the immune response to the antigens contained in these vaccines.
Chandola et al. (2017) studied this question.