COVID-19 Convalescent Plasma, A Targeted Therapy For Immunocompromised Patients With Severe COVID-19. About Two Cases And Review Of The Literature.

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IntroductionWhen immunocompromised patients are infected with COVID-19, the evolution towards a severe illness and even death is more likely than when dealing with immunocompetent patients.The best treatment regimen for these patients can be challenging to find, and the use of COVID-19 convalescent plasma can become necessary.We report two cases of immunocompromised patients treated with COVID-19 convalescent plasma, for which the outcome was satisfactory after treatment. Case Report 1:A 72-year-old patient with humoral immunodeficiency secondary to the treatment of lymphoma by anti-CD20 drugs.The patient tested positive for COVID-19 after a family reunion; he didn't have any symptoms at the time of testing.Three weeks later, he presented with a fever and respiratory symptoms.The chest CT scan showed ground-glass opacities.Further exploration of this condition led to the diagnosis of SARS-CoV-2 pulmonary infection.The patient received COVID-19 convalescent plasma, and his health improved rapidly afterward.He was declared cured forty-eight hours after having received the treatment. Case Report 2:A 52-year-old patient with humoral immunodeficiency secondary to the treatment of lymphoma by anti-CD20 drugs.He was tested for COVID-19 after having been in contact with a COVID-19-infected person; his test was positive.He didn't have any symptoms at the time of the testing.Two months later, he presented with dyspnea, coughing, and a fever.The chest CT-Scan found ground-glass opacities.After other analyses were done, the patient was diagnosed with SARS-CoV-2 pulmonary infection.He was treated with COVID-19 convalescent plasma and recovered to total health rapidly. ConclusionCOVID-19 convalescent plasma can be a therapeutic option to treat patients suffering from humoral immunodeficiency diagnosed with a severe COVID-19 infection.