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March 8, 2004Diabetes/Metabolism Research and Reviews

LDL oxidative modifications in well‐ or moderately controlled type 2 diabetes

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Why the study?

Is in vivo oxidation of LDL and carotid intima media thickness increased in patients with well- or moderately controlled type 2 diabetes compared to subjects with normal glucose metabolism?

Population

76 subjects, comprising 38 individuals with well- or moderately controlled type 2 diabetes and 38…

Comparison

Well- or moderately controlled type 2 diabetes vs Normal glucose metabolism

Design

Case-control

Authors

PSP SchefferUniversity of Applied Sciences UtrechtRHR.M.A. HenryMaastricht University Medical CentreEWEric WeverAmsterdam University Medical Centers

Discussion

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Implication

Increased LDL oxidation markers in T2D suggest persistent oxidative stress despite glycemic control; hypothesis-generating for vascular risk and requires prospective validation.

Structured PICO

Is in vivo oxidation of LDL and carotid intima media thickness increased in patients with well- or moderately controlled type 2 diabetes compared to subjects with normal glucose metabolism?

P
Population
76 subjects, comprising 38 individuals with well- or moderately controlled type 2 diabetes (HbA1c ≤ 8.5%) and 38 gender-matched subjects with normal glucose metabolism.
I
Intervention
Well- or moderately controlled type 2 diabetes
C
Comparator
Normal glucose metabolism (gender-matched control subjects)
O
Outcome
Indicators of free radical-mediated oxidation of LDL (baseline conjugated dienes, 7-OH-glycero-phosphocholine, lyso-phosphatidylcholine, ketocholesterol, and circulating in vivo oxidized apolipoprotein B100) and carotid intima media thickness (IMT)surrogate

Stable end products of LDL oxidation are significantly increased in patients with type 2 diabetes, indicating increased in vivo LDL oxidation even when glycemic control is well or moderately maintained.

Cite This Study

Scheffer et al. (2004) studied this question.

synapsesocial.com/papers/6a777b97d2fa2470761ee3cbhttps://doi.org/10.1002/dmrr.461
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Arterial Intima-Media Thickness and In Vivo LDL Oxidation in Young Men With Borderline Hypertension2000 · 134 citations
  2. 2Antibodies to Oxidized LDL in Relation to Intima-Media Thickness in Carotid and Femoral Arteries in 58-Year-Old Subjectively Clinically Healthy Men2001 · 105 citations
  3. 3Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23)1998 · 2,043 citations
  4. 4Associations of LDL size with in vitro oxidizability and plasma levels of in vivo oxidized LDL in Type 2 diabetic patients2003 · 58 citations
  5. 5Phospholipase A2 activity of low density lipoprotein: evidence for an intrinsic phospholipase A2 activity of apoprotein B-100.1990 · 138 citations