Key result
The top quintile of the LDL(NMR)/HDL(NMR) ratio was associated with increased CHD risk in men (OR 2.78; 95% CI 1.86-4.17) and women (OR 2.03; 95% CI 1.21-3.43) compared with the bottom quintile.
Why the study?
Do elevated lipoprotein ratios (TC/HDL-C, apoB/apoA-I, LDL(NMR)/HDL(NMR)) increase the risk of coronary heart disease in individuals from the EPIC-Norfolk study population?
Case-Control (n=2,529)
Do elevated lipoprotein ratios (TC/HDL-C, apoB/apoA-I, LDL(NMR)/HDL(NMR)) increase the risk of coronary heart disease in individuals from the EPIC-Norfolk study population?
Odds Ratio: 2.78 (95% CI 1.86–4.17)
TC/HDL-C, apoB/apoA-I, and NMR-based LDL/HDL ratios are similarly associated with metabolic syndrome components and increased risk of coronary heart disease.
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Supports NMR lipid ratios for CHD risk assessment; leaves open incremental value over conventional measures and should not change practice.
Arsenault et al. (2010) conducted a case-control in coronary heart disease (CHD) (n=2,529). Top quintile of LDL(NMR)/HDL(NMR) ratio vs. Bottom quintile of LDL(NMR)/HDL(NMR) ratio was evaluated on coronary heart disease (CHD) (OR 2.78, 95% CI 1.86-4.17). The top quintile of the LDL(NMR)/HDL(NMR) ratio was associated with increased CHD risk in men (OR 2.78; 95% CI 1.86-4.17) and women (OR 2.03; 95% CI 1.21-3.43) compared with the bottom quintile.
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