Key result
In patients with heart failure, renal clearance of milrinone was highly correlated with creatinine clearance during continuous intravenous infusion (R2=0.809, P<0.0001).
Why the study?
Does renal function correlate with plasma milrinone concentration during continuous intravenous infusion in heart failure patients?
Observational (n=10)
Does renal function correlate with plasma milrinone concentration during continuous intravenous infusion in heart failure patients?
Effect estimate: R2=0.809
p-value: p=<0.0001
Plasma milrinone concentration during continuous infusion can be estimated using creatinine clearance and body weight in heart failure patients, supporting dose adjustments in renal impairment.
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May support renal-based milrinone dosing estimates in heart failure; leaves open prospective validation of safety and outcomes.
Hasei et al. (2008) conducted an observational in Heart failure (n=10). Milrinone continuous intravenous infusion was evaluated on Correlation between renal clearance of milrinone and creatinine clearance (R2=0.809, p=<0.0001). In patients with heart failure, renal clearance of milrinone was highly correlated with creatinine clearance during continuous intravenous infusion (R2=0.809, P<0.0001).
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