Prediction of residual ischemic risk in ticagrelor-treated patients with acute coronary syndrome

Figures

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  Fig. 1. Distribution of ticagrelor platelet inhibiting rate measured by TEG in ACS patients. A and B represent the distribution of ADP% measured by TEG in derivation and validation group, respectively. C represent the distribution of ADP% in all included patients. ACS: acute coronary syndrome; ADP%: ADP-induced platelet inhibition rate; TEG: thromboelastography

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  Fig. 2. ROC curve for the prediction of ischemic events. A receiver-operating characteristic (ROC) analysis of ADP-induced platelet inhibition rate (ADP%) was used to distinguish patients with and without ischemic events. A. Prediction of primary ischemic events by ADP% in derivation group; B. Prediction of secondary ischemic events by ADP% in derivation group; C. Prediction of primary ischemic events by ADP% in validation group; D. Prediction of secondary ischemic events by ADP% in validation group. The primary ischemic events defined as the rehospitalization for unstable angina (UA) and the secondary ischemic events defined as the composite of rehospitalization for UA, all-cause death, nonfatal myocardial infarction (MI), stent thrombosis, stroke, and unplanned revascularization within 1 year. AUC: area under the curve

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  Fig. 3. Clinical outcomes within 1-year follow-up in derivation and validation group. The ADP% independently correlated with both primary and secondary events by using the cutoff of < 76%. A. 1-Year primary ischemic events in derivation group; B. 1-Year primary ischemic events in validation group; C. 1-Year secondary ischemic events in derivation group; D. 1-Year secondary ischemic events in validation group. Primary ischemic events were defined as rehospitalization for unstable angina (UA). Secondary ischemic events were defined as a composite of rehospitalization for UA, all-cause death, nonfatal myocardial infarction (MI), stent thrombosis, nonfatal stroke, and unplanned revascularization. *Adjusted by age, history of smoking, prior MI, hypertension, diabetes mellitus, and history of stroke

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  Fig. 4. Survival free of ischemic events during 1-year follow-up in patients with ADP-induced platelet inhibition rate (ADP%) < 76% and with ADP% ≥76%. A. 1-year primary ischemic survival events survival in derivation group; B. 1-year primary ischemic events survival in validation group; C. 1-year secondary ischemic events survival in derivation group; D. 1-year secondary ischemic events survival in validation group. Primary ischemic events were defined as rehospitalization for unstable angina (UA). Secondary ischemic events were defined as a composite of rehospitalization for UA, all-cause death, nonfatal myocardial infarction (MI), stent thrombosis, nonfatal stroke, and unplanned revascularization