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The disposition of pharmacologically active molecules in the maternal placental-fetal unit has been discussed in several recent books and reviews (1-3). Considerable data have accumulated to indicate that nearly all drugs enter the fetal circulation following maternal administration and may exert different effects upon the fetus. Hence, it is of considerable significance to determine the influence of biological maturation on placental transfer, the effects of drugs on placental function, fetal drug disposition, and the reac tivity of the fetus to pharmacologic agents. This review considers aspects of developmental pharmacology that have not been extensively considered in previous publications, examining in par ticular the following subject areas:
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Green et al. (1979) studied this question.
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