Key result
In a computer simulation of cardiac tissue, the diastolic threshold for anodal stimulation first decreased and then increased with increasing extracellular potassium concentration, reaching a minimum at 12 mM.
A mathematical model combining the Luo-Rudy model with the bidomain model demonstrates that the diastolic threshold for anodal stimulation reaches a minimum at an extracellular potassium concentration of 12mM.
Simulation results on anodal thresholds are hypothesis-generating; experimental validation required before clinical translation.
We report simulation of experimental data for heterogeneous distribution of extracellular potassium, by developing and applying a mathematical model formulated by incorporating a Luo-Rudy representation of the cell membrane current into the bidomain model of the cardiac tissue. Our model serves to examine propagation of extra cellular potassium from a region of low potassium (normal) to a region of high potassium (ischemic). Starting with computer simulation of unipolar stimulation of cardiac tissue, we reproduced results of the passive bidomain model, and also simulated the space-clamped Luo Rudy model. Finally, we combined the Luo-Rudy model with the bidomain model. The diastolic threshold for anodal stimulation first decreased and then increased with increasing potassium concentration ([K]0), reaching a minimum value at [K]0=12mM.
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Dhungana et al. (2015) studied Cardiac tissue electrophysiology (simulation). Inhomogeneous distribution of extracellular potassium vs. Normal extracellular potassium was evaluated on Action potential propagation and stimulus threshold. In a computer simulation of cardiac tissue, the diastolic threshold for anodal stimulation first decreased and then increased with increasing extracellular potassium concentration, reaching a minimum at 12 mM.
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