Key result
Intercellular coupling reduces transmural heterogeneity across ventricular tissue in computational models.
Why the study?
Heterogeneity in electrical activity across the ventricular wall may result from transmural differences in myocardial membrane ionic current densities, requiring computational modeling to understand excitation and propagation.
Computational modeling of guinea-pig ventricular tissue demonstrates that intercellular coupling reduces transmural electrical heterogeneity.
Heterogeneity in the electrical activity across the ventricular wall might result from transmural differences in myocardial membrane ionic current densities. Computational models of endo- and epi-cardial action potentials of guinea-pig myocytes were developed, assuming transmural differences in the ionic current densities and kinetics of i Kr and i Ks . The cell models were able to reproduce the characteristics of action potentials of endo and epi cells. One- and two-dimensional models of ventricular tissue were also developed to study the effects of transmural heterogeneity on the propagation of excitation waves across the ventricle wall. It was shown that intercellular coupling reduces the transmural heterogeneity across the ventricle wall.
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Li et al. (2003) studied Ventricular tissue electrophysiology. Computational modeling of endo- and epi-cardial action potentials was evaluated on Effects of transmural heterogeneity on the propagation of excitation waves. Computational models of guinea-pig ventricular tissue demonstrated that intercellular coupling reduces transmural heterogeneity across the ventricle wall.
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