Population
Mathematical electromechanical heart model composed of a human ionic cell model and a model for force…
Design
Preclinical
Key result
Mathematical modeling of regional heterogeneity demonstrated that action potential notch decreases from epicardium to endocardium and developed forces are largest in subendocardial cells.
Authors
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Incorporating regional heterogeneity improves cardiac electromechanical model fidelity; extends computational frameworks but leaves human translation open.
Mathematical modeling demonstrates the necessity of incorporating regional heterogeneity to accurately simulate human cardiac electromechanics.
Seemann et al. (2003) studied Cardiac electromechanics. Regional heterogeneity of electrophysiologic properties was evaluated on Electrophysiologic properties and cellular force development. Mathematical modeling of regional heterogeneity demonstrated that action potential notch decreases from epicardium to endocardium and developed forces are largest in subendocardial cells.