Why the study?
Variations in myocardial layer boundaries pose segmentation challenges, and the effects of differing transmural thickness ratios on arrhythmogenesis and mechanical responses remain unclear.
Does a thicker mid-myocardium improve pumping efficacy and reduce cardiac arrhythmia in a computational ventricular model?
Does a thicker mid-myocardium improve pumping efficacy and reduce cardiac arrhythmia in a computational ventricular model?
A thicker mid-myocardium in a computational model improves pumping efficacy and reduces the probability of sustained cardiac arrhythmia during reentry.
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May refine computational arrhythmia models; leaves open clinical validation of layer-specific predictions.
Dusturia et al. (2019) studied this question.
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